CCR2 antibody (C-Term)

Catalog No. ABIN2787667

The Rabbit Polyclonal anti-CCR2 antibody has been validated for WB. It is suitable to detect CCR2 in samples from Human, Dog, Cow and Horse. There are 2+ publications available.

Quick Overview for CCR2 antibody (C-Term) (ABIN2787667)

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Reactivity: Human, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCR2 Antibody

Binding Specificity: C-Term

Sequence: FTIMIVYFLF WTPYNIVILL NTFQEFFGLS NCESTSQLDQ ATQVTETLGM

Predicted Reactivity: Cow: 79%, Dog: 79%, Horse: 79%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CCR2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 374 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CCR2 antibody (ABIN2787667)

Toka, Dunaway, Smaltz, Szulc-Dąbrowska, Drnevich, Mielcarska, Bossowska-Nowicka, Schweizer: "Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line." in: BMC genomics, Vol. 20, Issue 1, pp. 15, (2019) (PubMed).

Murakami, Maeda, Yonezawa, Matsuki: "CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis." in: Veterinary immunology and immunopathology, Vol. 182, pp. 52-58, (2016) (PubMed).

Target Details for CCR2

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Alternative Name: CCR2

Background: This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.
Alias Symbols: CKR2, CCR-2, CCR2A, CCR2B, CD192, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2
Protein Size: 374

Molecular Weight: 42 kDa

Gene ID: 1231

NCBI Accession: NM_000647, NP_000638

UniProt: P41597

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process