ACTR1A antibody (Middle Region)

Catalog No. ABIN2787670

Product Details anti-ACTR1A Antibody

Target: ACTR1A (Alpha Centractin (ACTR1A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACTR1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AIKERACYLS INPQKDETLE TEKAQYYLPD GSTIEIGPSR FRAPELLFRP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ACTR1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ACTR1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 376 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACTR1A

Target: ACTR1A (Alpha Centractin (ACTR1A))

Alternative Name: ACTR1A (ACTR1A Products)

Synonyms: ARP1 antibody, CTRN1 antibody, Arp1 antibody, alpha-Arp1 antibody, arp1 antibody, centractin antibody, ctrn1 antibody, ACTR1A antibody, ARP1 actin related protein 1 homolog A antibody, ARP1 actin-related protein 1A, centractin alpha antibody, ARP1 actin-related protein 1 homolog A, centractin alpha antibody, ARP1 actin related protein 1 homolog A L homeolog antibody, alpha-centractin antibody, actin-2 antibody, ACTR1A antibody, Actr1a antibody, actr1a.L antibody, actr1a antibody, PTRG_02540 antibody, PAAG_06972 antibody, MCYG_01044 antibody, VDBG_00685 antibody, MGYG_00946 antibody, DICPUDRAFT_88548 antibody, PGTG_04034 antibody, Tsp_06409 antibody

Background: ACTR1A is a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin.This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARP1, CTRN1
Protein Interaction Partner: HUWE1, SUMO2, UBC, NUP133, DCTN4, MYCBP, DCTN3, DCTN2, ACTR1B, LMNB1, COG3, ACTR10, SMURF1, RRS1, PSMD1, PSMC4, MYH9, MCM7, COPS5, CUL1, CUL3, SUMO1, Cep76, Actr1a, Dctn1, Capza1, HDAC6, SPTBN2, SPTBN1, NUMA1, BICD2,
Protein Size: 376

Molecular Weight: 41 kDa

Gene ID: 10121

NCBI Accession: NM_005736, NP_005727

UniProt: P61163

Pathways: M Phase