IVD antibody (N-Term)

Catalog No. ABIN2787703

The Rabbit Polyclonal anti-IVD antibody (ABIN2787703) specifically detects IVD in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse and Rabbit samples.

Quick Overview for IVD antibody (N-Term) (ABIN2787703)

Target: IVD (Isovaleryl-CoA Dehydrogenase (IVD))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IVD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IVD Antibody

Binding Specificity: N-Term

Purpose: IVD Antibody - N-terminal region

Sequence: APKAQEIDRS NEFKNLREFW KQLGNLGVLG ITAPVQYGGS GLGYLEHVLV

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against IVD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human IVD

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58485-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IVD

Target: IVD (Isovaleryl-CoA Dehydrogenase (IVD))

Alternative Name: IVD

Background:

Background Information: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia.

Gene Name: isovaleryl-CoA dehydrogenase

Alternative Symbols: IVDH, ACAD2

Protein Name: Isovaleryl-CoA dehydrogenase, mitochondrial

Molecular Weight: 46kDa

Gene ID: 3712

UniProt: P26440

Pathways: Monocarboxylic Acid Catabolic Process