ATG4C antibody (Middle Region)

Catalog No. ABIN2787855

This Rabbit Polyclonal antibody specifically detects ATG4C in WB. It exhibits reactivity toward Human, Cow, Horse and Dog.

Quick Overview for ATG4C antibody (Middle Region) (ABIN2787855)

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reactivity: Human, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG4C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATG4C Antibody

Binding Specificity: Middle Region

Purpose: ATG4C Antibody - middle region

Sequence: TISLKETIGK YSDDHEMRNE VYHRKIISWF GDSPLALFGL HQLIEYGKKS

Predicted Reactivity: Cow: 75%, Dog: 91%, Horse: 86%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ATG4C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATG4C

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58863-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATG4C

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Alternative Name: ATG4C

Background:

Background Information: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.

Gene Name: ATG4 autophagy related 4 homolog C (S. cerevisiae)

Alternative Symbols: APG4C, AUTL1, AUTL3, APG4-C

Protein Name: Cysteine protease ATG4C

Molecular Weight: 52kDa

Gene ID: 84938

NCBI Accession: NP_835739

UniProt: Q96DT6

Pathways: Autophagy