DRAM antibody (N-Term)

Catalog No. ABIN2787866

The Rabbit Polyclonal anti-DRAM antibody is suitable to detect DRAM in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for DRAM antibody (N-Term) (ABIN2787866)

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRAM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DRAM Antibody

Binding Specificity: N-Term

Sequence: TMYTRYKIVQ KQNQTCYFST PVFNLVSLVL GLVGCFGMGI VANFQELAVP

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against DRAM. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DRAM

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 238 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DRAM

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Alternative Name: DRAM

Background: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
Alias Symbols: DRAM, FLJ11259
Protein Interaction Partner: C1orf21, APP,
Protein Size: 238

Molecular Weight: 26 kDa

Gene ID: 55332

NCBI Accession: NM_018370, NP_060840

UniProt: Q8N682