Caspase 7 antibody (N-Term)

Catalog No. ABIN2787907

This anti-Caspase 7 antibody is a Rabbit Polyclonal antibody detecting Caspase 7 in WB. Suitable for Human, Mouse, Rat, Pig, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Cow and Goat.

Quick Overview for Caspase 7 antibody (N-Term) (ABIN2787907)

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reactivity: Human, Mouse, Rat, Pig, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Cow, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Caspase 7 Antibody

Binding Specificity: N-Term

Sequence: NNKNFDKVTG MGVRNGTDKD AEALFKCFRS LGFDVIVYND CSCAKMQDLL

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CASP7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 336 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Alternative Name: CASP7

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
Alias Symbols: CMH-1, ICE-LAP3, MCH3
Protein Interaction Partner: PTGES3, BAX, PARP1, SAT1, CRYAB, XIAP, RPS6KA1, CTSA, PEPD, MVD, GNS, GBP2, EEF2, CAPN1, CNDP2, GINS2, EIF4H, GZMB, ROCK1, DFFA, CASP9, CASP7, CASP3, ARHGDIA, VIM, STAT1, SPTAN1, CLSPN, PLA2G4B, RB1, UBC, BIRC2, CCT2, VCP, SP1, BIRC3, BIRC6, COPS6, TERF1,
Protein Size: 336

Molecular Weight: 37 kDa

Gene ID: 840

NCBI Accession: NM_033338, NP_203124

UniProt: P55210

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity