IL7R antibody (Middle Region)

Catalog No. ABIN2787929

The Rabbit Polyclonal anti-IL7R antibody has been validated for WB. It is suitable to detect IL7R in samples from Human, Horse and Dog.

Quick Overview for IL7R antibody (Middle Region) (ABIN2787929)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reactivity: Human, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL7R antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL7R Antibody

Binding Specificity: Middle Region

Sequence: ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP

Predicted Reactivity: Dog: 92%, Horse: 83%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against IL7R. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IL7R

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 459 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Alternative Name: IL7R

Background: The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: KIT, JAK3, SNRPG, SNRPD3, SNRPD2, SNRPD1, SNRPB, SNRPA, SNRNP70, SRSF3, SAFB, RPS20, RPS3, RPL31, RPL29, RPL30, RPL22, RPL18, RPL15, RPL8, RPL7, RPL6, RBM3, PURB, PURA, PTMA, PTBP1, EIF2AK2, YBX1, NONO, NCL, MAP4, RPSA, ILF3, ILF2, HNRNPU, HNRNPL, HNRNPH3
Protein Size: 459

Molecular Weight: 49 kDa

Gene ID: 3575

NCBI Accession: NM_002185, NP_002176

UniProt: P16871

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size