Selectin E/CD62e antibody (N-Term)

Catalog No. ABIN2787940

This Rabbit Polyclonal antibody specifically detects Selectin E/CD62e in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Sheep, Cow and Horse.

Quick Overview for Selectin E/CD62e antibody (N-Term) (ABIN2787940)

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Sheep, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Selectin E/CD62e antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Selectin E/CD62e Antibody

Binding Specificity: N-Term

Purpose: SELE Antibody - N-terminal region

Sequence: WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK DVGMWNDERC

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against SELE. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SELE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59109-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Selectin E/CD62e

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Alternative Name: SELE

Background:

Background Information: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

Gene Name: Selectin E

Alternative Symbols: ELAM, ESEL, CD62E, ELAM1, LECAM2

Protein Name: E-selectin

Molecular Weight: 64kDa

Gene ID: 6401

NCBI Accession: NP_000441

UniProt: P16581

Pathways: Thromboxane A2 Receptor Signaling