TIM3 antibody (C-Term)

Catalog No. ABIN2787957

The Rabbit Polyclonal anti-TIM3 antibody is suitable to detect TIM3 in samples from Human, Dog, Cow and Horse. It has been validated for WB.

Quick Overview for TIM3 antibody (C-Term) (ABIN2787957)

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Reactivity: Human, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIM3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIM3 Antibody

Binding Specificity: C-Term

Purpose: HAVCR2 Antibody - C-terminal region

Sequence: IGIYIGAGIC AGLALALIFG ALIFKWYSHS KEKIQNLSLI SLANLPPSGL

Predicted Reactivity: Cow: 83%, Dog: 82%, Horse: 91%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against HAVCR2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HAVCR2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59159-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TIM3

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Alternative Name: HAVCR2

Background:

Background Information: HAVCR2 regulates macrophage activation. HAVCR2 inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. HAVCR2 may be also involved in T-cell homing. HAVCR2 is the receptor for LGALS9.

Gene Name: Hepatitis A virus cellular receptor 2

Alternative Symbols: TIM3, CD366, KIM-3, SPTCL, TIMD3, Tim-3, TIMD-3, HAVcr-2

Protein Name: Hepatitis A virus cellular receptor 2

Molecular Weight: 33kDa

Gene ID: 84868

NCBI Accession: NP_116171

UniProt: Q8TDQ0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints