TIMP1 antibody (N-Term)

Catalog No. ABIN2787966

This Rabbit Polyclonal antibody specifically detects TIMP1 in WB. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Dog, Horse, Sheep, Cow, Goat and Guinea Pig.

Quick Overview for TIMP1 antibody (N-Term) (ABIN2787966)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reactivity: Human, Rat, Mouse, Rabbit, Dog, Horse, Sheep, Cow, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIMP1 Antibody

Binding Specificity: N-Term

Purpose: TIMP1 Antibody - N-terminal region

Sequence: QRYEIKMTKM YKGFQALGDA ADIRFVYTPA MESVCGYFHR SHNRSEEFLI

Predicted Reactivity: Cow: 93%, Dog: 86%, Goat: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 79%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against TIMP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TIMP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59178-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Alternative Name: TIMP1

Background:

Background Information: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Gene Name: TIMP metallopeptidase inhibitor 1

Alternative Symbols: EPA, EPO, HCI, CLGI, TIMP, TIMP-1

Protein Name: TIMP metallopeptidase inhibitor 1 EMBL CAI42465.1

Molecular Weight: 23kDa

Gene ID: 7076

NCBI Accession: NP_003245

UniProt: Q6FGX5