KNG1 antibody (N-Term)

Catalog No. ABIN2787975

This Rabbit Polyclonal antibody specifically detects KNG1 in WB. It exhibits reactivity toward Human, Rat and Pig.

Quick Overview for KNG1 antibody (N-Term) (ABIN2787975)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNG1 Antibody

Binding Specificity: N-Term

Purpose: KNG1 Antibody - N-terminal region

Sequence: ALKKYNSQNQ SNNQFVLYRI TEATKTVGSD TFYSFKYEIK EGDCPVQSGK

Predicted Reactivity: Human: 100%, Pig: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against KNG1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human KNG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59203-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background:

Background Information: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII and inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects such as influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, etc.

Gene Name: kininogen 1

Alternative Symbols: BK, BDK, KNG, HMWK

Protein Name: Kininogen-1 Ensembl ENSP00000396025

Molecular Weight: 43kDa

Gene ID: 3827

NCBI Accession: NP_001159923

UniProt: C9JEX1

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process