alpha 2 Macroglobulin antibody (N-Term)

Catalog No. ABIN2787981

Product Details anti-alpha 2 Macroglobulin Antibody

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PVPGHVTVSI CRKYSDASDC HGEDSQAFCE KFSGQLNSHG CFYQQVKTKV

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against A2M. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1474 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2M (A2M Products)

Synonyms: A2MD antibody, CPAMD5 antibody, FWP007 antibody, S863-7 antibody, A2MAC1 antibody, A2m1 antibody, A2maa antibody, Mam antibody, A2mp antibody, A2M antibody, LOC733429 antibody, endod antibody, cpamd5 antibody, fwp007 antibody, s863-7 antibody, a2mb antibody, endodermin antibody, Alpha-2-M antibody, alpha-2-macroglobulin antibody, pregnancy-zone protein L homeolog antibody, alpha-2-macroglobulin S homeolog antibody, pregnancy zone protein antibody, alpha-2-macroglobulin-like antibody, A2M antibody, A2m antibody, LOC477699 antibody, pzp.L antibody, AZL_c00450 antibody, LOC100349077 antibody, a2m antibody, LOC100061656 antibody, LOC100090399 antibody, a2m.S antibody, LOC100469973 antibody, LOC100595735 antibody, PZP antibody, LOC100353095 antibody, LOC101122940 antibody, LOC101801552 antibody, LOC100911545 antibody

Background: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Alias Symbols: CPAMD5, DKFZp779B086, FWP007, S863-7, A2MD
Protein Interaction Partner: MAPK6, CDK7, CDK11A, HIPK1, FBXO6, CFTR, TP63, TGM2, IFIT3, DNAJB1, GCDH, FARSA, ENO2, ELAVL3, CYP2C18, CYP2C8, ATP1A1, APP, APOE, ACTB, A2M, RNF32, SWSAP1, TRAPPC5, EVI5L, EGLN2, IGSF8, PRAM1, MLST8, STAMBPL1, RETN, FBXL12, ECSIT, FIS1, EXOSC1, IFIT5, NC
Protein Size: 1474

Molecular Weight: 161 kDa

Gene ID: 2

NCBI Accession: NM_000014, NP_000005

UniProt: P01023

Pathways: Lipid Metabolism