alpha 2 Macroglobulin antibody (N-Term)

Catalog No. ABIN2787981

The Rabbit Polyclonal anti-alpha 2 Macroglobulin antibody (ABIN2787981) specifically detects alpha 2 Macroglobulin in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for alpha 2 Macroglobulin antibody (N-Term) (ABIN2787981)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-alpha 2 Macroglobulin Antibody

Binding Specificity: N-Term

Purpose: A2M Antibody - N-terminal region

Sequence: PVPGHVTVSI CRKYSDASDC HGEDSQAFCE KFSGQLNSHG CFYQQVKTKV

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against A2M. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59224-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2M

Background:

Background Information: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Gene Name: Alpha-2-macroglobulin

Alternative Symbols: A2MD, CPAMD5, FWP007, S863-7

Protein Name: Alpha-2-macroglobulin

Molecular Weight: 161kDa

Gene ID: 2

NCBI Accession: NP_000005

UniProt: P01023

Pathways: Lipid Metabolism