RECK antibody (Middle Region)

Catalog No. ABIN2787984

The Rabbit Polyclonal anti-RECK antibody is suitable to detect RECK in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit and Horse. It has been validated for WB.

Quick Overview for RECK antibody (Middle Region) (ABIN2787984)

Target: RECK (Reversion-Inducing-Cysteine-Rich Protein with Kazal Motifs (RECK))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RECK Antibody

Binding Specificity: Middle Region

Sequence: SCIVGGKRKS HGTSFTIDCN VCSCFAGNLV CSTRLCLSEH SSDDDRRTFT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Reck. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 971 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RECK

Target: RECK (Reversion-Inducing-Cysteine-Rich Protein with Kazal Motifs (RECK))

Alternative Name: Reck

Background: Reck negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. It appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Alias Symbols: MGC169689, St15, mRECK
Protein Size: 971

Molecular Weight: 104 kDa

Gene ID: 53614

NCBI Accession: NM_016678, NP_057887

UniProt: Q9Z0J1