SERPINB8 antibody (C-Term)

Catalog No. ABIN2787992

The Rabbit Polyclonal anti-SERPINB8 antibody is suitable to detect SERPINB8 in samples from Human, Mouse, Rat, Dog, Rabbit, Cow, Horse and Guinea Pig. It has been validated for WB.

Quick Overview for SERPINB8 antibody (C-Term) (ABIN2787992)

Target: SERPINB8 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 (SERPINB8))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SERPINB8 Antibody

Binding Specificity: C-Term

Sequence: LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE AKFKMGYADE

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SERPINB8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SERPINB8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 242 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SERPINB8

Target: SERPINB8 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 (SERPINB8))

Alternative Name: SERPINB8

Background: The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8, SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).
Alias Symbols: CAP2, PI8
Protein Interaction Partner: SUMO2, LARS, UBC, CAP1, PRSS1, F10, F2, FURIN, BCL2,
Protein Size: 242

Molecular Weight: 27 kDa

Gene ID: 5271

NCBI Accession: NM_001031848, NP_001027018

UniProt: Q8N178