PSMC6 antibody (C-Term)

Catalog No. ABIN2788038

The Rabbit Polyclonal anti-PSMC6 antibody (ABIN2788038) specifically detects PSMC6 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Guinea Pig and Saccharomyces cerevisiae samples.

Quick Overview for PSMC6 antibody (C-Term) (ABIN2788038)

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSMC6 Antibody

Binding Specificity: C-Term

Sequence: GFNGADLRNV CTEAGMFAIR ADHDFVVQED FMKAVRKVAD SKKLESKLDY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 86%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMC6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMC6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 389 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMC6

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Alternative Name: PSMC6

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Alias Symbols: CADP44, MGC12520, P44, SUG2, p42
Protein Interaction Partner: SDCBP, CCDC146, CYB5R2, HUWE1, UBC, PSMD9, PSMC6, PSMC3, SUMO2, STAU1, PSMD14, MDM2, ABCF1, UBR4, ADRM1, TXNL1, AIMP1, AIMP2, RPS21, RPS15A, RPS12, RPS8, QARS, PSMD12, PSMD11, PSMD8, PSMD4, UCHL5, DYNC1LI1, PSMD3, PSMD2, PSMD1, PSMC5, PSMC2, PSMC1, PARK2,
Protein Size: 389

Molecular Weight: 44 kDa

Gene ID: 5706

NCBI Accession: NM_002806, NP_002797

UniProt: P62333

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway