PSMC6 antibody (AA 20-150)

Catalog No. ABIN6146328

The Rabbit Polyclonal anti-PSMC6 antibody is suitable to detect PSMC6 in samples from Human. It has been validated for WB.

Quick Overview for PSMC6 antibody (AA 20-150) (ABIN6146328)

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSMC6 Antibody

Binding Specificity: AA 20-150

Sequence: DKALQDYRKK LLEHKEIDGR LKELREQLKE LTKQYEKSEN DLKALQSVGQ IVGEVLKQLT EEKFIVKATN GPRYVVGCRR QLDKSKLKPG TRVALDMTTL TIMRYLPREV DPLVYNMSHE DPGNVSYSEI G

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PSMC6 (NP_002797.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PSMC6

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Alternative Name: PSMC6

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.,PSMC6,CADP44,HEL-S-73,P44,SUG2,p42,ATPase 6,Cell Biology & Developmental Biology,Ubiquitin,PSMC6

Molecular Weight: 44 kDa

Gene ID: 5706

UniProt: P62333

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway