FBXL12 antibody (C-Term)

Catalog No. ABIN2788057

This Rabbit Polyclonal antibody specifically detects FBXL12 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit, Cow and Horse.

Quick Overview for FBXL12 antibody (C-Term) (ABIN2788057)

Target: FBXL12 (F-Box and Leucine-Rich Repeat Protein 12 (FBXL12))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXL12 Antibody

Binding Specificity: C-Term

Sequence: PTEILSSCLT MPKLRVLELQ GLGWEGQEAE KILCKGLPHC MVIVRACPKE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FBXL12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FBXL12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 326 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL12

Target: FBXL12 (F-Box and Leucine-Rich Repeat Protein 12 (FBXL12))

Alternative Name: FBXL12

Background: Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Alias Symbols: FLJ20188, Fbl12
Protein Interaction Partner: LNX1, DOCK8, PRAME, STYX, HSP90AA1, CUL1, SKP1, RNF32, ECSIT, MAST1, CDC37, PSEN2, PSEN1, APOE, A2M, UBC, COPS6, RBX1, CDKN1C, JUN, FXYD3, SMAD1, TGFBR1,
Protein Size: 326

Molecular Weight: 37 kDa

Gene ID: 54850

NCBI Accession: NM_017703, NP_060173

UniProt: Q9NXK8

Pathways: SARS-CoV-2 Protein Interactome