PEN2 antibody (C-Term)

Catalog No. ABIN2788066

The Rabbit Polyclonal anti-PEN2 antibody (ABIN2788066) specifically detects PEN2 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for PEN2 antibody (C-Term) (ABIN2788066)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PEN2 Antibody

Binding Specificity: C-Term

Sequence: SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSENEN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 101 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PSENEN

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A, ERLIN2, THBD, APH1B, PSEN2, PSEN1, TMED10, NCSTN,
Protein Size: 101

Molecular Weight: 12 kDa

Gene ID: 55851

NCBI Accession: NM_172341, NP_758844

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway