MYRIP antibody (C-Term)

Catalog No. ABIN2788071

The Rabbit Polyclonal anti-MYRIP antibody is suitable to detect MYRIP in samples from Human, Dog, Horse and Pig. It has been validated for WB.

Quick Overview for MYRIP antibody (C-Term) (ABIN2788071)

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Reactivity: Human, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYRIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYRIP Antibody

Binding Specificity: C-Term

Purpose: MYRIP Antibody - C-terminal region

Sequence: QQRRKLPAPP VKAEKIETSS VTTIKTFNHN FILQGSSTNR TKERKGTTKD

Predicted Reactivity: Dog: 86%, Horse: 93%, Human: 100%, Pig: 93%

Characteristics: This is a rabbit polyclonal antibody against MYRIP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYRIP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59445-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MYRIP

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Alternative Name: MYRIP

Background:

Background Information: MYRIP is a rab effector protein involved in melanosome transport. It serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. It may link RAB27A-containing vesicles to actin filaments, functions as a protein kinase A-anchoring protein (AKAP) and may act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.

Gene Name: myosin VIIA and Rab interacting protein

Alternative Symbols: SLAC2C, SLAC2-C

Protein Name: Rab effector MyRIP

Molecular Weight: 73kDa

Gene ID: 25924

UniProt: Q8NFW9

Pathways: Positive Regulation of Peptide Hormone Secretion