AVPR2 antibody (C-Term)

Catalog No. ABIN2788110

The Rabbit Polyclonal anti-AVPR2 antibody has been validated for WB. It is suitable to detect AVPR2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep and Horse.

Quick Overview for AVPR2 antibody (C-Term) (ABIN2788110)

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AVPR2 Antibody

Binding Specificity: C-Term

Sequence: NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against AVPR2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AVPR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 371 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AVPR2

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Alternative Name: AVPR2

Background: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
Alias Symbols: ADHR, DI1, DIR, DIR3, MGC126533, MGC138386, NDI, V2R
Protein Interaction Partner: ARRDC4, ARRDC3, GNG2, GNB1, GNAS, STUB1, UBC, DERL1, VCP, C1QTNF1, GRK5, AVP, ARRB2, MAPK3, PRKCA,
Protein Size: 371

Molecular Weight: 40 kDa

Gene ID: 554

NCBI Accession: NM_000054, NP_000045

UniProt: P30518

Pathways: cAMP Metabolic Process