GPR172A antibody (C-Term)

Catalog No. ABIN2788146

The Rabbit Polyclonal anti-GPR172A antibody (ABIN2788146) specifically detects GPR172A in WB. The antibody is reactive with Human, Mouse, Rat, Pig, Horse, Guinea Pig, Dog and Cow samples.

Quick Overview for GPR172A antibody (C-Term) (ABIN2788146)

Target: GPR172A (G Protein-Coupled Receptor 172A (GPR172A))

Reactivity: Human, Mouse, Rat, Pig, Horse, Guinea Pig, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR172A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GPR172A Antibody

Binding Specificity: C-Term

Purpose: SLC52A2 Antibody - C-terminal region

Sequence: SLPSVTTGGS GPELQLGSPG AEEEEKEEEE ALPLQEPPSQ AAGTIPGPDP

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 85%, Pig: 93%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against SLC52A1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human SLC52A2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59638-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GPR172A

Target: GPR172A (G Protein-Coupled Receptor 172A (GPR172A))

Alternative Name: SLC52A2

Background:

Background Information: This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia.

Gene Name: solute carrier family 52 (riboflavin transporter), member 2

Alternative Symbols: PAR1, RFT3, RFVT2, hRFT3, BVVLS2, GPCR41, GPR172A, D15Ertd747e

Protein Name: solute carrier family 52, riboflavin transporter, member 2

Molecular Weight: 38kDa

Gene ID: 79581

NCBI Accession: NP_001240744

UniProt: Q9HAB3

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response