BBS10 antibody (C-Term)

Catalog No. ABIN2788220

The Rabbit Polyclonal anti-BBS10 antibody (ABIN2788220) specifically detects BBS10 in WB. The antibody is reactive with Human and Rabbit samples.

Quick Overview for BBS10 antibody (C-Term) (ABIN2788220)

Target: BBS10 (Bardet-Biedl Syndrome 10 (BBS10))

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BBS10 Antibody

Binding Specificity: C-Term

Purpose: BBS10 Antibody - C-terminal region

Sequence: SQTGLESVMG KYQLLTSVLQ CLTKILTIDM VITVKRHPQK VHNQDSEDEL

Predicted Reactivity: Human: 100%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against BBS10. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BBS10

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59803-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BBS10

Target: BBS10 (Bardet-Biedl Syndrome 10 (BBS10))

Alternative Name: BBS10

Background:

Background Information: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.

Gene Name: Bardet-Biedl syndrome 10

Alternative Symbols: C12orf58

Protein Name: Bardet-Biedl syndrome 10 protein

Molecular Weight: 81kDa

Gene ID: 79738

NCBI Accession: NP_078961

UniProt: Q8TAM1