CERKL antibody (C-Term)

Catalog No. ABIN2788232

This anti-CERKL antibody is a Rabbit Polyclonal antibody detecting CERKL in WB. Suitable for Human, Mouse, Rabbit, Horse, Dog, Guinea Pig, Rat, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for CERKL antibody (C-Term) (ABIN2788232)

Target: CERKL (Ceramide Kinase-Like (CERKL))

Reactivity: Human, Mouse, Rabbit, Horse, Dog, Guinea Pig, Rat, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CERKL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CERKL Antibody

Binding Specificity: C-Term

Sequence: ASVKNQFNFP FVETYTVEEV KVHPRNNTGG YNPEEEEDET ASENCFPWNV

Predicted Reactivity: Dog: 90%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 81%, Rat: 79%, Yeast: 89%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against CERKL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CERKL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 463 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CERKL

Target: CERKL (Ceramide Kinase-Like (CERKL))

Alternative Name: CERKL

Background: This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.
Alias Symbols: RP26
Protein Size: 463

Molecular Weight: 51 kDa

Gene ID: 375298

NCBI Accession: NM_001030313, NP_001025484

UniProt: Q49MI3