BTBD12 antibody (N-Term)

Catalog No. ABIN2788239

This anti-BTBD12 antibody is a Rabbit Polyclonal antibody detecting BTBD12 in WB. Suitable for Human and Rabbit.

Quick Overview for BTBD12 antibody (N-Term) (ABIN2788239)

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BTBD12 Antibody

Binding Specificity: N-Term

Sequence: TKTLQGPAEK KPPSGSQAPR TKKQRVTKWQ ASEPAHSVNG EGGVLASAPD

Predicted Reactivity: Human: 100%, Rabbit: 91%

Characteristics: This is a rabbit polyclonal antibody against BTBD12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BTBD12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1834 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BTBD12

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Alternative Name: BTBD12

Background: This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
Alias Symbols: KIAA1784, KIAA1987, MUS312, SLX4, FANCP, BTBD12
Protein Interaction Partner: MUS81, vpr, SLX1A, SLX1B, DCLRE1B, TERF2, ERCC4, UBC, ERCC1, APP, EME1, PCNA, MSH2, MSH6, DDB1, SLX4IP, SPRTN, TERF2IP, VCP, PLK1, SUMO2, PGAM5, DCAF10, LRRC1, GID8, TEX10, GLTSCR2, NUP188, NUP50, PNMA2, TSPYL1, PSMB4, MSH3, KPNA1,
Protein Size: 1834

Molecular Weight: 200 kDa

Gene ID: 84464

NCBI Accession: NM_032444, NP_115820

UniProt: Q8IY92

Pathways: DNA Damage Repair