MAGE-Like 2 antibody (N-Term)

Catalog No. ABIN2788252

Product Details anti-MAGE-Like 2 Antibody

Target: MAGE-Like 2 (MAGEL2)

Binding Specificity: N-Term

Reactivity: Human, Cow, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGE-Like 2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MQGLFYRPQG SSKERRTSSK ERRAPSKDRM IFAATFCAPK AVSAARAHLP

Predicted Reactivity: Cow: 83%, Dog: 100%, Human: 100%, Pig: 88%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against MAGEL2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAGEL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 529 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAGE-Like 2

Target: MAGE-Like 2 (MAGEL2)

Alternative Name: MAGEL2 (MAGEL2 Products)

Synonyms: NDNL1 antibody, nM15 antibody, MAGEL2 antibody, Mage-l2 antibody, ns7 antibody, MAGE family member L2 antibody, melanoma antigen, family L, 2 antibody, MAGEL2 antibody, Magel2 antibody

Background: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
Alias Symbols: NDNL1, nM15
Protein Interaction Partner: VPS35, VPS26A, USP7, TRIM27, UBC,
Protein Size: 529

Molecular Weight: 58 kDa

Gene ID: 54551

NCBI Accession: NM_019066

UniProt: Q9UJ55