MAGE-Like 2 antibody (N-Term)

Catalog No. ABIN2788252

The Rabbit Polyclonal anti-MAGE-Like 2 antibody is suitable to detect MAGE-Like 2 in samples from Human, Cow, Dog, Pig and Rabbit. It has been validated for WB.

Quick Overview for MAGE-Like 2 antibody (N-Term) (ABIN2788252)

Target: MAGE-Like 2 (MAGEL2)

Reactivity: Human, Cow, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGE-Like 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAGE-Like 2 Antibody

Binding Specificity: N-Term

Purpose: MAGEL2 Antibody - N-terminal region

Sequence: MQGLFYRPQG SSKERRTSSK ERRAPSKDRM IFAATFCAPK AVSAARAHLP

Predicted Reactivity: Cow: 83%, Dog: 100%, Human: 100%, Pig: 88%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against MAGEL2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAGEL2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59891-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAGE-Like 2

Target: MAGE-Like 2 (MAGEL2)

Alternative Name: MAGEL2

Background:

Background Information: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.

Gene Name: MAGE-like 2

Alternative Symbols: PWLS, nM15, NDNL1, SHFYNG

Protein Name: MAGE-like protein 2

Molecular Weight: 58kDa

Gene ID: 54551

UniProt: Q9UJ55