ADRA2A antibody (C-Term)

Catalog No. ABIN2788284

The Rabbit Polyclonal anti-ADRA2A antibody has been validated for WB. It is suitable to detect ADRA2A in samples from Human, Rat, Mouse, Dog, Cow, Guinea Pig and Pig.

Quick Overview for ADRA2A antibody (C-Term) (ABIN2788284)

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADRA2A Antibody

Binding Specificity: C-Term

Sequence: RRPERGPRGK GKARASQVKP GDSLPRRGPG ATGIGTPAAG PGEERVGAAK

Predicted Reactivity: Cow: 92%, Dog: 85%, Guinea Pig: 79%, Human: 100%, Mouse: 79%, Pig: 85%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ADRA2A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ADRA2A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 450 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ADRA2A

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Alternative Name: ADRA2A

Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons, the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
Alias Symbols: ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Protein Interaction Partner: GNAO1, ADRA2A, SNTA1, GNG2, GNB1, GNAI2, UCHL1, EIF2B1, YWHAZ, PRKCD, GNAI1, ADRBK1, ADRB1, PPP1R9B,
Protein Size: 450

Molecular Weight: 49 kDa

Gene ID: 150

NCBI Accession: NM_000681, NP_000672

UniProt: P08913

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity