ADRA2C antibody (C-Term)

Catalog No. ABIN2788285

The Rabbit Polyclonal anti-ADRA2C antibody (ABIN2788285) specifically detects ADRA2C in WB. The antibody is reactive with Human and Pig samples.

Quick Overview for ADRA2C antibody (C-Term) (ABIN2788285)

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADRA2C Antibody

Binding Specificity: C-Term

Purpose: ADRA2C Antibody - C-terminal region

Sequence: RAGAEGGAGG ADGQGAGPGA AESGALTASR EWGGERGRPL CLPPSARGCF

Predicted Reactivity: Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against ADRA2C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ADRA2C

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59968-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ADRA2C

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Alternative Name: ADRA2C

Background:

Background Information: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Gene Name: adrenoceptor alpha 2C

Alternative Symbols: ADRA2L2, ADRARL2, ADRA2RL2, ALPHA2CAR

Protein Name: alpha-2C adrenergic receptor

Molecular Weight: 41kDa

Gene ID: 152

NCBI Accession: NP_000674

UniProt: P18825

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process