Factor VII antibody (Middle Region)

Catalog No. ABIN2788317

Product Details anti-Factor VII Antibody

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Cow, Rabbit, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor VII antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RCHEGYSLLA DGVSCTPTVE YPCGKIPILE KRNASKPQGR IVGGKVCPKG

Predicted Reactivity: Cow: 86%, Horse: 86%, Human: 100%, Pig: 79%, Rabbit: 85%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against F7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human F7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 466 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Alternative Name: F7 (F7 Products)

Background: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
Alias Symbols: SPCA
Protein Interaction Partner: FUS, CEP76, CEP250, VCP, RCHY1, ALB, UIMC1, USP49, DMWD, F9, F10, F7, HPN, GGCX, F3,
Protein Size: 466

Molecular Weight: 52 kDa

Gene ID: 2155

NCBI Accession: NM_000131, NP_000122

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling