CTSC antibody (Middle Region)
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- Target See all CTSC Antibodies
- CTSC (Cathepsin C (CTSC))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Cow, Dog, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CTSC antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- WTATTYMEYE TLTLGDMIRR SGGHSRKIPR PKPAPLTAEI QQKILHLPTS
- Predicted Reactivity
- Cow: 86%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%
- Characteristics
- This is a rabbit polyclonal antibody against CTSC. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CTSC
- Top Product
- Discover our top product CTSC Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 463 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CTSC (Cathepsin C (CTSC))
- Alternative Name
- CTSC (CTSC Products)
- Synonyms
- CPPI antibody, DPP-I antibody, DPP1 antibody, DPPI antibody, HMS antibody, JP antibody, JPD antibody, PALS antibody, PDON1 antibody, PLS antibody, MGC69126 antibody, MGC107782 antibody, AI047818 antibody, CATC antibody, cb912 antibody, ik:tdsubc_1h2 antibody, sb:cb146 antibody, wu:fb34g12 antibody, wu:fj58d01 antibody, cathepsin C antibody, cathepsin C L homeolog antibody, cathepsin CPC1 antibody, CTSC antibody, ctsc.L antibody, ctsc antibody, TP03_0357 antibody, CMU_003360 antibody, CPC1 antibody, NAEGRDRAFT_80477 antibody, NAEGRDRAFT_37577 antibody, Ctsc antibody, Smp_183330 antibody
- Background
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CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Alias Symbols: CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I
Protein Interaction Partner: SUMO1, UBC, NEDD8, ARMC9, ANKMY2, ARIH1, UBA2, ADSL, FBXO6, XRN2, CAPN1, CD81, CTSC, CTSL,
Protein Size: 463 - Molecular Weight
- 8 kDa
- Gene ID
- 1075
- NCBI Accession
- NM_001814, NP_001805
- UniProt
- P53634
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