TCHP antibody (C-Term)

Catalog No. ABIN2788476

Product Details anti-TCHP Antibody

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCHP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against TCHP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 498 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TCHP antibody (ABIN2788476)

Wong, Vaz, Lee, Zhao, Luo, Archer, Preiss, Tanavde, Vardy: "Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation." in: PLoS ONE, Vol. 11, Issue 1, pp. e0143235, (2016) (PubMed).

Target Details for TCHP

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Alternative Name: TCHP (TCHP Products)

Synonyms: TpMs antibody, A930031F18Rik antibody, AV279199 antibody, RGD1310813 antibody, zgc:136634 antibody, trichoplein keratin filament binding antibody, trichoplein, keratin filament binding antibody, trichoplein, keratin filament binding L homeolog antibody, TCHP antibody, tchp antibody, Tchp antibody, tchp.L antibody

Background: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Alias Symbols: MGC10854, TpMs
Protein Interaction Partner: CCDC172, MIPOL1, DYDC1, KRT40, LZTS2, NME7, NDOR1, MKRN3, TRIM27, NAB2, KRT15, CDR2, UBC, LATS2, CUL4A, CCDC85B, TEX11, VIM, KRT18, KRT16, KRT14, KRT8, KRT6A, KRT5,
Protein Size: 498

Molecular Weight: 61 kDa

Gene ID: 84260

NCBI Accession: NM_032300, NP_115676

UniProt: Q9BT92