TCHP antibody (C-Term)

Catalog No. ABIN2788476

There is 1 publication for this product available. The Rabbit Polyclonal anti-TCHP antibody is suitable to detect TCHP in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for TCHP antibody (C-Term) (ABIN2788476)

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCHP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TCHP Antibody

Binding Specificity: C-Term

Purpose: TCHP Antibody - C-terminal region

Sequence: IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against TCHP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60515-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-TCHP antibody (ABIN2788476)

Wong, Vaz, Lee, Zhao, Luo, Archer, Preiss, Tanavde, Vardy: "Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation." in: PLoS ONE, Vol. 11, Issue 1, pp. e0143235, (2016) (PubMed).

Target Details for TCHP

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Alternative Name: TCHP

Background:

Background Information: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Gene Name: Trichoplein, keratin filament binding

Alternative Symbols: TpMs

Protein Name: Trichoplein keratin filament-binding protein

Molecular Weight: 61kDa

Gene ID: 84260

NCBI Accession: NP_115676

UniProt: Q9BT92