IL-21 antibody (C-Term)

Catalog No. ABIN2788558

This Rabbit Polyclonal antibody specifically detects IL-21 in WB. It exhibits reactivity toward Human, Cow, Horse, Pig, Dog, Goat and Sheep.

Quick Overview for IL-21 antibody (C-Term) (ABIN2788558)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Human, Cow, Horse, Pig, Dog, Goat, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-21 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-21 Antibody

Binding Specificity: C-Term

Sequence: ERIINVSIKK LKRKPPSTNA GRRQKHRLTC PSCDSYEKKP PKEFLERFKS

Predicted Reactivity: Cow: 79%, Dog: 86%, Goat: 86%, Horse: 79%, Human: 100%, Pig: 86%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against IL21. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL21

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: IL21

Background: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: IL-21, Za11
Protein Interaction Partner: FBXO25, IL21R, DGKA,
Protein Size: 153

Molecular Weight: 16 kDa

Gene ID: 59067

NCBI Accession: NM_001207006, NP_001193935

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response