HPSE antibody (N-Term)

Catalog No. ABIN2788567

This Rabbit Polyclonal antibody specifically detects HPSE in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Guinea Pig.

Quick Overview for HPSE antibody (N-Term) (ABIN2788567)

Target: HPSE (Heparanase (HPSE))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HPSE antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HPSE Antibody

Binding Specificity: N-Term

Purpose: HPSE Antibody - N-terminal region

Sequence: DPRFLILLGS PKLRTLARGL SPAYLRFGGT KTDFLIFDPK KESTFEERSY

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against HPSE. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HPSE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60765-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HPSE

Target: HPSE (Heparanase (HPSE))

Alternative Name: HPSE

Background:

Background Information: Heparan sulfate proteoglycans (HSPGs) are major components of the basement membrane and extracellular matrix. Heparanases, like HSPE, are endoglycosidases that cleave the heparan sulfate side chain of HSPGs to permit the remodeling of the extracellular matrix for cell movement or the release of bioactive molecules from the extracellular matrix or cell surface.

Gene Name: Heparanase

Alternative Symbols: HPA, HPA1, HPR1, HSE1, HPSE1

Protein Name: Heparanase

Molecular Weight: 61kDa

Gene ID: 10855

NCBI Accession: NP_006656

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process