ACER1 antibody (C-Term)

Catalog No. ABIN2788591

The Rabbit Polyclonal anti-ACER1 antibody (ABIN2788591) specifically detects ACER1 in WB. The antibody is reactive with Human, Rat, Cow, Guinea Pig, Rabbit, Dog and Pig samples.

Quick Overview for ACER1 antibody (C-Term) (ABIN2788591)

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Reactivity: Human, Rat, Cow, Guinea Pig, Rabbit, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACER1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACER1 Antibody

Binding Specificity: C-Term

Purpose: ACER1 Antibody - C-terminal region

Sequence: VNAYALNSIA LHILYIVCQE YRKTSNKELR HLIEVSVVLW AVALTSWISD

Predicted Reactivity: Cow: 79%, Dog: 92%, Guinea Pig: 75%, Human: 100%, Pig: 85%, Rabbit: 86%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against ACER1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ACER1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60812-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACER1

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Alternative Name: ACER1

Background:

Background Information: ACER1 hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. It has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. It may have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.

Gene Name: Alkaline ceramidase 1

Alternative Symbols: ASAH3, ALKCDase1

Protein Name: Alkaline ceramidase 1

Molecular Weight: 31kDa

Gene ID: 125981

NCBI Accession: NP_597999

UniProt: Q8TDN7