Calpain 3 antibody (C-Term)

Catalog No. ABIN2788627

This Rabbit Polyclonal antibody specifically detects Calpain 3 in WB. It exhibits reactivity toward Human, Rat, Cow, Sheep, Dog, Horse, Guinea Pig and Rabbit.

Quick Overview for Calpain 3 antibody (C-Term) (ABIN2788627)

Target: Calpain 3 (CAPN3)

Reactivity: Human, Rat, Cow, Sheep, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Calpain 3 Antibody

Binding Specificity: C-Term

Purpose: CAPN3 Antibody - C-terminal region

Sequence: DRANSNKELG VDQESEEGKG KTSPDKQKQS PQPQPGSSDQ ESEEQQQFRN

Predicted Reactivity: Cow: 79%, Dog: 92%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Rabbit: 86%, Rat: 85%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against CAPN3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60946-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Calpain 3

Target: Calpain 3 (CAPN3)

Alternative Name: CAPN3

Background:

Background Information: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Gene Name: Calpain 3, (p94)

Alternative Symbols: p94, CANP3, LGMD2, nCL-1, CANPL3, LGMD2A, LGMDD4, LGMDR1

Protein Name: Calpain-3

Molecular Weight: 93kDa

Gene ID: 825

NCBI Accession: NP_077320

UniProt: P20807

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development