Cathepsin K antibody (Middle Region)
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- Target See all Cathepsin K (CTSK) Antibodies
- Cathepsin K (CTSK)
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Dog, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Goat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cathepsin K antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- SPQNLVDCVS ENDGCGGGYM TNAFQYVQKN RGIDSEDAYP YVGQEESCMY
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Goat: 82%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
- Characteristics
- This is a rabbit polyclonal antibody against CTSK. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CTSK
- Top Product
- Discover our top product CTSK Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 329 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Cathepsin K (CTSK)
- Alternative Name
- CTSK (CTSK Products)
- Synonyms
- CTS02 antibody, CTSO antibody, CTSO1 antibody, CTSO2 antibody, PKND antibody, PYCD antibody, AI323530 antibody, MMS10-Q antibody, Ms10q antibody, catK antibody, CTSK antibody, wu:fa95f03 antibody, wu:fb08b05 antibody, zgc:110367 antibody, cts02 antibody, ctso antibody, ctso1 antibody, ctso2 antibody, pknd antibody, pycd antibody, OC-2 antibody, catk antibody, cathepsin K antibody, cathepsin K L homeolog antibody, Cathepsin K antibody, CTSK antibody, Ctsk antibody, ctsk antibody, ctsk.L antibody, catk antibody
- Background
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The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
Alias Symbols: CTS02, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD
Protein Interaction Partner: LIG4, SERPINB13, SERPINB3, KNG1, SPARC, FGFR3,
Protein Size: 329 - Molecular Weight
- 37 kDa
- Gene ID
- 1513
- NCBI Accession
- NM_000396, NP_000387
- UniProt
- P43235
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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