HIST1H2AE antibody (Middle Region)

Catalog No. ABIN2788645

The Rabbit Polyclonal anti-HIST1H2AE antibody (ABIN2788645) specifically detects HIST1H2AE in WB. The antibody is reactive with Human, Cow, Rat and Pig samples.

Quick Overview for HIST1H2AE antibody (Middle Region) (ABIN2788645)

Target: HIST1H2AE (Histone Cluster 1, H2ae (HIST1H2AE))

Reactivity: Human, Cow, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIST1H2AE antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HIST1H2AE Antibody

Binding Specificity: Middle Region

Purpose: HIST1H2AE Antibody - middle region

Sequence: TAEILELAGN AARDNKKTRI IPRHLQLAIR NDEELNKLLG RVTIAQGGVL

Predicted Reactivity: Cow: 100%, Human: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HIST1H2AE. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60986-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIST1H2AE

Target: HIST1H2AE (Histone Cluster 1, H2ae (HIST1H2AE))

Alternative Name: HIST1H2AE

Background:

Background Information: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Gene Name: Histone cluster 1, H2ae

Alternative Symbols: H2A.1, H2A.2, H2A/a, H2AC4, H2AFA, HIST1H2AE

Protein Name: Histone H2A type 3

Molecular Weight: 14kDa

Gene ID: 3012

NCBI Accession: NP_066390

UniProt: Q7L7L0

Pathways: Telomere Maintenance