BID antibody (C-Term)

Catalog No. ABIN2788659

This Rabbit Polyclonal antibody specifically detects BID in WB and IF. It exhibits reactivity toward Human, Dog and Horse.

Quick Overview for BID antibody (C-Term) (ABIN2788659)

Target: BID (BH3 Interacting Domain Death Agonist (BID))

Reactivity: Human, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BID antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-BID Antibody

Binding Specificity: C-Term

Sequence: LRNTSRSEED RNRDLATALE QLLQAYPRDM EKEKTMLVLA LLLAKKVASH

Predicted Reactivity: Dog: 86%, Horse: 86%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against BID. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 241 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BID

Target: BID (BH3 Interacting Domain Death Agonist (BID))

Alternative Name: BID

Background: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8), CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
Alias Symbols: FP497, MGC15319, MGC42355
Protein Interaction Partner: AHCYL1, REL, MCL1, BCL2, BCL2L1, GZMB, CASP3, BAG3, CAV1, SQSTM1, VCP, UBQLN2, RPA2, RPA1, UBC, TUBB2B, FBN3, RBM48, CRNKL1, ZHX1, C14orf1, SETDB1, PLEKHM1, TLE1, GBP2, GAPDH, CRMP1, ITCH, BID, BCL2L2, CASP8, CASP10, YWHAB, BCL2A1, CSNK1E, CASP2, BAK1, CS
Protein Size: 241

Molecular Weight: 27 kDa

Gene ID: 637

NCBI Accession: NM_197966, NP_932070

UniProt: B3KT21

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity