SYK antibody (Middle Region)

Catalog No. ABIN2788676

The Rabbit Polyclonal anti-SYK antibody has been validated for WB. It is suitable to detect SYK in samples from Human, Pig and Horse.

Quick Overview for SYK antibody (Middle Region) (ABIN2788676)

Target: SYK (Spleen tyrosine Kinase (SYK))

Reactivity: Human, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SYK Antibody

Binding Specificity: Middle Region

Sequence: RIKSYSFPKP GHRKSSPAQG NRQESTVSFN PYEPELAPWA ADKGPQREAL

Predicted Reactivity: Horse: 85%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against SYK. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 635 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Alternative Name: SYK

Background: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DKFZp313N1010, FLJ25043, FLJ37489, p72-Syk
Protein Interaction Partner: SH2D2A, TRAF6, STAT3, USP25, IL17RA, TRAF3IP2, PTPRO, UBC, FCGR3A, TICAM1, TLR9, TBK1, TRAF3, TLR4, TLR3, MAP3K7, MYD88, SRC, SYK, UBASH3B, VCAM1, ITGA4, ERBB4, ERBB3, ERBB2, EGFR, APP, SH3BP2, MAPT, TUBB, VAV2, VAV1, PIK3CG, BLNK, CBL, BTK, PIK3R1, TRAIP
Protein Size: 635

Molecular Weight: 72 kDa

Gene ID: 6850

NCBI Accession: NM_003177, NP_003168

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling