SORD antibody (N-Term)

Catalog No. ABIN2788686

The Rabbit Polyclonal anti-SORD antibody (ABIN2788686) specifically detects SORD in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Sheep, Dog, Rabbit, Pig, Guinea Pig and Horse samples.

Quick Overview for SORD antibody (N-Term) (ABIN2788686)

Target: SORD (Sorbitol Dehydrogenase (SORD))

Reactivity: Human, Mouse, Rat, Cow, Sheep, Dog, Rabbit, Pig, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SORD Antibody

Binding Specificity: N-Term

Purpose: SORD Antibody - N-terminal region

Sequence: ASGTVEKVGS SVKHLKPGDR VAIEPGAPRE NDEFCKMGRY NLSPSIFFCA

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against SORD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SORD

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61128-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SORD

Target: SORD (Sorbitol Dehydrogenase (SORD))

Alternative Name: SORD

Background:

Background Information: Sorbitol dehydrogenase (SORD, EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1, MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.

Gene Name: Sorbitol dehydrogenase

Alternative Symbols: RDH, SDH, XDH, SORD1, SORDD, HEL-S-95n

Protein Name: Sorbitol dehydrogenase

Molecular Weight: 38kDa

Gene ID: 6652

NCBI Accession: NP_003095

UniProt: Q00796