Endothelin 3 antibody (C-Term)

Catalog No. ABIN2788707

This anti-Endothelin 3 antibody is a Rabbit Polyclonal antibody detecting Endothelin 3 in WB. Suitable for Human and Pig.

Quick Overview for Endothelin 3 antibody (C-Term) (ABIN2788707)

Target: Endothelin 3 (EDN3)

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Endothelin 3 Antibody

Binding Specificity: C-Term

Sequence: LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL

Predicted Reactivity: Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against EDN3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EDN3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 219 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Alias Symbols: ET3, MGC15067, MGC61498, ET-3, WS4B, HSCR4, PPET3
Protein Interaction Partner: EDNRB, EDNRA, CMA1, CTSE, KEL,
Protein Size: 219

Molecular Weight: 24 kDa

Gene ID: 1908

NCBI Accession: NM_207032, NP_996915

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones