IL2 Receptor beta antibody (C-Term)

Catalog No. ABIN2788713

This Rabbit Polyclonal antibody specifically detects IL2 Receptor beta in WB. It exhibits reactivity toward Human, Rat and Saccharomyces cerevisiae.

Quick Overview for IL2 Receptor beta antibody (C-Term) (ABIN2788713)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Human, Rat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL2 Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL2 Receptor beta Antibody

Binding Specificity: C-Term

Sequence: QGYFFFHLPD ALEIEACQVY FTYDPYSEED PDEGVAGAPT GSSPQPLQPL

Predicted Reactivity: Human: 100%, Rat: 77%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against IL2RB. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 551 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: IL2RB

Background: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
Alias Symbols: CD122, P70-75, IL15RB
Protein Interaction Partner: ECM1, JAK1, SOCS3, LCK, NEDD4, HGS, UBC, EIF3B, STAT5B, SOCS1, CISH, STAT5A, IL15RA, SHC1, STAT1, IL15, SHB, JAK3, SYK, IL2RG, GNB2L1, PTPN6, PIK3R1, LYN, RAF1, IL2RA, IL2, FYN, GRB2, STAT3, JAK2,
Protein Size: 551

Molecular Weight: 58 kDa

Gene ID: 3560

NCBI Accession: NM_000878, NP_000869

UniProt: P14784

Pathways: JAK-STAT Signaling, Growth Factor Binding