IRAK2 antibody (C-Term)

Catalog No. ABIN2788725

The Rabbit Polyclonal anti-IRAK2 antibody is suitable to detect IRAK2 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for IRAK2 antibody (C-Term) (ABIN2788725)

Target: IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRAK2 Antibody

Binding Specificity: C-Term

Sequence: SSSEACVGLE PPQDVTETSW QIEINEAKRK LMENILLYKE EKVDSIELFG

Predicted Reactivity: Cow: 93%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against IRAK2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IRAK2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 625 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRAK2

Target: IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))

Alternative Name: IRAK2

Background: IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
Alias Symbols: IRAK-2, MGC150550
Protein Interaction Partner: TNFSF9, TRAF6, HSP90AA1, PSEN1, IRAK1, IL1R1, MYD88, UBC, TIRAP, SESTD1, ZC3H12C, ZC3H12A, FASTKD5, ADCK3, YTHDF1, TOLLIP, IRAK4, TARDBP, SARM1, SNRNP200, IRAK3, CDC37, IQSEC1, IQCB1, BAG3, STT3A, ARAF, TNFAIP3, MME, TICAM2, SMURF1, IRAK2, TLR4, SMAD2, HR
Protein Size: 625

Molecular Weight: 69 kDa

Gene ID: 3656

NCBI Accession: NM_001570, NP_001561

UniProt: O43187

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades