OGG1 antibody (C-Term)

Catalog No. ABIN2788728

This anti-OGG1 antibody is a Rabbit Polyclonal antibody detecting OGG1 in WB. Suitable for Human, Mouse, Rat, Dog, Horse, Cow and Pig.

Quick Overview for OGG1 antibody (C-Term) (ABIN2788728)

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OGG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OGG1 Antibody

Binding Specificity: C-Term

Sequence: AVPVDVHMWH IAQRDYSWHP TTSQAKGPSP QTNKELGNFF RSLWGPYAGW

Specificity: Directed against isoforms 2D, 1A, 1B, 2E.

Predicted Reactivity: Cow: 93%, Dog: 100%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 92%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against OGG1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 345 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1

Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.
Alias Symbols: HMMH, HOGG1, MUTM, OGH1
Protein Interaction Partner: ERCC6, ERCC8, UBC, Ogg1, CHGB, XRCC1, PRKCA, SNRPF,
Protein Size: 345

Molecular Weight: 38 kDa

Gene ID: 4968

NCBI Accession: NM_016829, NP_058438

UniProt: O15527

Pathways: DNA Damage Repair