GBA antibody (C-Term)

Catalog No. ABIN2788767

The Rabbit Polyclonal anti-GBA antibody has been validated for WB. It is suitable to detect GBA in samples from Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for GBA antibody (C-Term) (ABIN2788767)

Target: GBA (Glucosidase, Beta, Acid (GBA))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GBA Antibody

Binding Specificity: C-Term

Sequence: EGSQRVGLVA SQKNDLDAVA LMHPDGSAVV VVLNRSSKDV PLTIKDPAVG

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 83%, Pig: 100%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against GBA. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 536 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GBA

Target: GBA (Glucosidase, Beta, Acid (GBA))

Alternative Name: GBA

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Alias Symbols: GBA1, GCB, GLUC
Protein Interaction Partner: NUDCD1, UBC, ITCH, ATP6V1B1, SNCA, FBXO6, TCP1, CBL, NEDD4, PARK2, HSP90AA1, HSPA4, PSAP,
Protein Size: 536

Molecular Weight: 59 kDa

Gene ID: 2629

NCBI Accession: NM_000157, NP_000148

UniProt: P04062

Pathways: Cellular Glucan Metabolic Process