GRK6 antibody (C-Term)

Catalog No. ABIN2788810

The Rabbit Polyclonal anti-GRK6 antibody (ABIN2788810) specifically detects GRK6 in WB. The antibody is reactive with Human, Rat, Horse, Dog, Guinea Pig, Rabbit and Cow samples.

Quick Overview for GRK6 antibody (C-Term) (ABIN2788810)

Target: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Reactivity: Human, Rat, Horse, Dog, Guinea Pig, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRK6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRK6 Antibody

Binding Specificity: C-Term

Sequence: LYEMIAGQSP FQQRKKKIKR EEVERLVKEV PEEYSERFSP QARSLCSQLL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GRK6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GRK6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 589 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GRK6

Target: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Alternative Name: GRK6

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: FLJ32135, GPRK6
Protein Interaction Partner: UBC, ADRB2, TBXA2R, MMS19, ITGA5, HSP90AA1, DDB1, KCNIP3, HSP90AB1, EDNRB, PRSS23, GIT1, SLC9A3R1, LTB4R, GRK6, RHO, RCVRN, SNCA, FSHR, EDNRA, CHRM3, BDKRB2, SNCG, SNCB,
Protein Size: 589

Molecular Weight: 67 kDa

Gene ID: 2870

NCBI Accession: NM_002082, NP_002073

UniProt: Q96AD6

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity