SURF1 antibody (N-Term)

Catalog No. ABIN2788832

The Rabbit Polyclonal anti-SURF1 antibody is suitable to detect SURF1 in samples from Human, Cow, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for SURF1 antibody (N-Term) (ABIN2788832)

Target: SURF1 (Surfeit 1 (SURF1))

Reactivity: Human, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SURF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SURF1 Antibody

Binding Specificity: N-Term

Purpose: SURF1 Antibody - N-terminal region

Sequence: GLRAAGLGRA PASAAWRSVL RVSPRPGVAW RPSRCGSSAA EASATKAEDD

Predicted Reactivity: Cow: 79%, Guinea Pig: 86%, Horse: 86%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SURF1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61537-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SURF1

Target: SURF1 (Surfeit 1 (SURF1))

Alternative Name: SURF1

Background:

Background Information: This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.

Gene Name: Surfeit 1

Alternative Symbols: SHY1, CMT4K, MC4DN1

Protein Name: Surfeit locus protein 1

Molecular Weight: 33kDa

Gene ID: 6834

NCBI Accession: NP_003163

UniProt: Q15526

Pathways: Proton Transport, Ribonucleoside Biosynthetic Process