CDK11 antibody (Middle Region)

Catalog No. ABIN2788891

The Rabbit Polyclonal anti-CDK11 antibody (ABIN2788891) specifically detects CDK11 in WB. The antibody is reactive with Human, Mouse, Cow, Pig, Rat, Zebrafish (Danio rerio), Saccharomyces cerevisiae, Rabbit, Horse and Dog samples.

Quick Overview for CDK11 antibody (Middle Region) (ABIN2788891)

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Reactivity: Human, Mouse, Cow, Pig, Rat, Zebrafish (Danio rerio), Saccharomyces cerevisiae, Rabbit, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK11 Antibody

Binding Specificity: Middle Region

Purpose: CDK11B Antibody - middle region

Sequence: REQEKELREQ EKELREQKEL REQEEQMQEQ EEKMWEQEEK MREQEEKMWR

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 90%

Characteristics: This is a rabbit polyclonal antibody against LOC283685. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDK11B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61760-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDK11

Target: CDK11 (CDK11B) (Cyclin-Dependent Kinase 11B (CDK11B))

Alternative Name: CDK11B

Background:

Background Information: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants.

Gene Name: cyclin-dependent kinase 11B

Alternative Symbols: p58, PK58, CDK11, CLK-1, CDC2L1, PITSLREA, p58CLK-1, CDK11-p46, CDK11-p58, p58CDC2L1, CDK11-p110

Protein Name: cyclin-dependent kinase 11B

Molecular Weight: 34kDa

Gene ID: 984

NCBI Accession: NP_277022

UniProt: P21127

Pathways: Regulation of Lipid Metabolism by PPARalpha, M Phase