PFKFB1 antibody (C-Term)

Catalog No. ABIN2788933

The Rabbit Polyclonal anti-PFKFB1 antibody (ABIN2788933) specifically detects PFKFB1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio) and Rabbit samples.

Quick Overview for PFKFB1 antibody (C-Term) (ABIN2788933)

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKFB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PFKFB1 Antibody

Binding Specificity: C-Term

Purpose: PFKFB1 Antibody - C-terminal region

Sequence: CPLHTVLKLT PVAYGCKVES IYLNVEAVNT HREKPENVDI TREPEEALDT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PFKFB1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61878-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PFKFB1

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Alternative Name: PFKFB1

Background:

Background Information: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Alternative Symbols: F6PK, HL2K, PFRX

Protein Name: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 EMBL AAH96078.1

Molecular Weight: 52kDa

Gene ID: 5207

NCBI Accession: NP_002616

UniProt: Q4VBA8

Pathways: Regulation of Carbohydrate Metabolic Process