BAG4 antibody (C-Term)

Catalog No. ABIN2788953

This Rabbit Polyclonal antibody specifically detects BAG4 in WB. It exhibits reactivity toward Human, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit and Pig.

Quick Overview for BAG4 antibody (C-Term) (ABIN2788953)

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reactivity: Human, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAG4 Antibody

Binding Specificity: C-Term

Purpose: BAG4 Antibody - C-terminal region

Sequence: PSAPPGNLYM TESTSPWPSS GSPQSPPSPP VQQPKDSSYP YSQSDQSMNR

Predicted Reactivity: Cow: 91%, Dog: 100%, Guinea Pig: 77%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against BAG4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61938-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Alternative Name: BAG4

Background:

Background Information: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Gene Name: BCL2-associated athanogene 4

Alternative Symbols: SODD, BAG-4

Protein Name: BAG family molecular chaperone regulator 4

Molecular Weight: 46kDa

Gene ID: 9530

NCBI Accession: NP_001191807

UniProt: B4E217

Pathways: Regulation of Actin Filament Polymerization