ORC3 antibody (N-Term)

Catalog No. ABIN2789072

The Rabbit Polyclonal anti-ORC3 antibody (ABIN2789072) specifically detects ORC3 in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Pig, Rabbit, Zebrafish (Danio rerio) and Saccharomyces cerevisiae samples.

Quick Overview for ORC3 antibody (N-Term) (ABIN2789072)

Target: ORC3 (Origin Recognition Complex, Subunit 3 (ORC3))

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ORC3 Antibody

Binding Specificity: N-Term

Purpose: ORC3L Antibody - N-terminal region

Sequence: RFETYQLIWQ QMKSENERLQ EELNKNLFDN LIEFLQKSHS GFQKNSRDLG

Predicted Reactivity: Cow: 93%, Dog: 93%, Human: 100%, Mouse: 79%, Pig: 90%, Rabbit: 93%, Rat: 83%, Yeast: 90%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against ORC3L. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62224-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ORC3

Target: ORC3 (Origin Recognition Complex, Subunit 3 (ORC3))

Alternative Name: ORC3L

Background:

Targeted Subunit: 3

Background Information: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Gene Name: Origin recognition complex, subunit 3

Alternative Symbols: LAT, ORC3L, LATHEO

Protein Name: Origin recognition complex subunit 3

Molecular Weight: 82kDa

Gene ID: 23595

NCBI Accession: NP_862820

UniProt: Q9UBD5

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Feeding Behaviour, Synthesis of DNA